Scientific Research &  Clinical Studies

HEALTHY AGING

Scientific Review:

Healthful aging mediated by inhibition of oxidative stress

Ageing research reviews 2020

Pub Med Abstract only: https://pubmed.ncbi.nlm.nih.gov/33091597/

Scientific Review:

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

International journal of molecular sciences 2019

Pubmed Abstract: https://pubmed.ncbi.nlm.nih.gov/31510091/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769561/#sec8-ijms-20-04472title

Scientific Review:

Oxidative stress, aging, and diseases

Clinical interventions in aging (Journal) 2018

Pub Med Abstract:https://pubmed.ncbi.nlm.nih.gov/29731617/

Full Article (Of note Page 5: Oxidative Stress and the Theory of Aging) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927356/#__sec2title

Clinical Study:

Frailty syndrome is associated with altered circulating redox balance and increased markers of oxidative stress

International journal of immunopathology and pharmacology 2009

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/19822098/

Full Clinical Study: https://journals.sagepub.com/doi/pdf/10.1177/039463200902200328

GLUTATHIONE & AGING WELL

 

Clinical Study:

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation

The American journal of clinical nutrition 2011

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/21795440/

Full Clinical Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155927/

Scientific Review:

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/16321806/

Full Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569588/

CO Q10 & AGING WELL

 

Scientific Review:

Coenzyme Q 10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

International journal of molecular sciences 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/33114148/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660335/

Scientific Review:

Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview

Antioxidants (Basel, Switzerland) 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/30781472/

NAD+ & AGING WELL

 

Systematic Review:

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

Experimental gerontology 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/31917996/

Scientific Review:

NAD and the aging process: Role in life, death and everything in between

Molecular and cellular endocrinology 2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/27825999/

Scientific Review:

NAD+ and sirtuins in aging and disease

Trends in cell biology 2014

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24786309/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112140/

Clinical Study:

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue

Public Library of Science 2012

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/22848760/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407129/

SKIN AGING & OXIDATIVE STRESS

 

Scientific Review:

Oxidative stress and antioxidant strategies in dermatology

Redox report : communications in free radical research 2016

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/26020527/

Full Article: https://www.tandfonline.com/doi/pdf/10.1179/1351000215Y.0000000015?needAccess=true

Scientific Review:

Oxidative stress in aging human skin

Biomolecules (Journal) 2015

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/25906193/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496685/

Scientific Review:

Skin photoaging and the role of antioxidants in its prevention

International Scholarly Research Network - Dermatology 2013

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24159392/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789494/

Clinical Study:

Aging- and photoaging-dependent changes of enzymic and nonenzymic antioxidants in the epidermis and dermis of human skin in vivo

The Journal of investigative dermatology 2001

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/11710935/

Full Article: https://www.jidonline.org/action/showPdf?pii=S0022-202X%2815%2941443-5

Scientific Study:

Low levels of glutathione are sufficient for survival of keratinocytes after UV irradiation and for healing of mouse skin wounds

Archives of Dermatological Research 2016

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/27262586/

Randomised Clinical Study:

Glutathione and its antiaging and antimelanogenic effects

Clinical, cosmetic and investigational dermatology (Journal)  2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/28490897/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413479/

Excerpt: Conclusion: We showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms effectively influences skin properties. Overall, glutathione in both forms are well tolerated.

Scientific Study:

Coenzyme Q10, a cutaneous (SKIN) antioxidant and energizer

BioFactors (Oxford, England) 1999

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/10416055/

Excerpt: The processes of aging and photoaging are associated with an increase in cellular oxidation. This may be in part due to a decline in the levels of the endogenous cellular antioxidant coenzyme Q10 (ubiquinone, CoQ10)

Scientific Review:

The evolving role of the NAD+/nicotinamide metabolome in skin homeostasis, cellular bioenergetics, and aging

DNA repair (Journal) 2014

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24794404/

Excerpt: Since UV-induced oxidative stress in skin can disrupt these processes, continued molecular understanding of the role of NAD+ and nicotinamide in skin biology is important to identify interventions that would help maintain its normal homeostatic functions and efficient cellular bioenergetics.

CHRONIC FATIGUE & OXIDATIVE STRESS

Clinical Study:

Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue

Scientific reports (Journal) 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/30150620/

Full Study Results: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110864/

Excerpt:  Our results confirmed that oxidative stress is a key contributor in the pathophysiology of Idiopathic Chronic Fatigue (ICF), and firstly explored the features of oxidative stress parameters in ICF subjects compared to a healthy population

Clinical Study:

Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms

Free radical biology & medicine 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/16085177/

Excerpt: This is the first time that raised levels of the gold standard measure of in vivo oxidative stress (isoprostanes) and their association with Chronic Fatigue Syndrome (CFS) symptoms have been reported.

 

Scientific Review:

Chronic fatigue syndrome: oxidative stress and dietary modifications

Alternative medicine review : a journal of clinical therapeutic 2001

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/11703165/

Full Publication: http://archive.foundationalmedicinereview.com/publications/6/5/450.pdf

Excerpt: The etiology of Chronic  Syndrome (CFS) remains unclear; however, a number of recent studies have shown oxidative stress may be involved in its pathogenesis. The role of oxidative stress in CFS is an important area for current and future research as it suggests the use of antioxidants in the management of CFS. Specifically, the dietary supplements glutathione, N-acetylcysteine, alpha-lipoic acid,........

Clinical Study:

Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome

Neuroscience letters 2003

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/12531455/

Excerpt: Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome.

Scientific  Review:

The glutathione system: a new drug target in neuroimmune disorders

Molecular neurobiology (Journal) 2014

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24752591/

Excerpt: Glutathione (GSH) depletion and concomitant increase in Oxidative &Nitosative Stress and mitochondrial dysfunctions play a role in the pathophysiology of diverse neuroimmune disorders, including depression, myalgic encephalomyelitis/chronic fatigue syndrome and Parkinson's disease, suggesting that depleted GSH is an integral part of these diseases.

Pre-Clinical Study:

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome

Journal of medicinal food 2002

Pub Me Abstract: https://pubmed.ncbi.nlm.nih.gov/12639396/

Excerpt:  The findings strongly suggest that oxidative stress plays a significant role in the pathophysiology of Chronic Fatigue Syndrome (CFS) and that antioxidants could be useful in the treatment of CFS.

Scientific Study:

Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: A possible approach to SARS-CoV-2 'long-

haulers'?

Chronic diseases and translational medicine (Journal) 2021

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/33251031/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680046/

Excerpt:  It also reviews what is known about oxidative stress and how this can be related to the pathophysiology of fatigue, as well as examining the potential for specific therapy directed at mitochondria for the treatment of chronic fatigue in the form of antioxidants. 

Scientific Review:

Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?

Metabolic brain disease (Journal) 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/30758706/

Full Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428797/

Excerpt: A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with a consideration of the post-infection role of damage-associated molecular patterns and the development of chronic inflammatory, oxidative and nitrosative stress in genetically predisposed individuals.

BURNOUT, OXIDATIVE STRESS & ANTIOXIDANTS

Clinical Study:

Physiological correlates of burnout among women

Journal of psychosomatic research 2003

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/14507541/

Excerpt: Objectives: The purpose of this study was to investigate the immune, endocrine, and metabolic correlates of burnout among women.

Conclusions: Among women, burnout seems to involve enhanced inflammatory responses and oxidative stress.

Clinical Study:

Antioxidant enzymes, occupational stress and burnout in workers of a prehospitalary emergency service

European journal of emergency medicine 2005

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/15891442/

Excerpt: Background: Reactive oxygen species (ROS) play an important role in many diseases and aging. Scavenging enzymes represent one of several natural defence mechanisms against ROS-induced damage. Superoxide dismutase (SOD) and catalase are enzymes that are involved in antioxidant defence. Burnout is a syndrome of emotional exhaustion, depersonalization, and reduced personal accomplishment.

Clinical Study:

Determination of oxidative and occupational stress in palliative care workers

Clinical chemistry and laboratory medicine (Journal) 2011

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/21143019/

Full Study Results: https://digital.csic.es/bitstream/10261/76171/4/Clin%20Chem%20Lab%20Med%202011-%c3%81ngela%20Casado.pdf

Excerpt: Conclusions: Our findings suggest that oxidative stress, occupational stress and occupational burnout levels are similar in men and women. Occupational stress increases oxidative stress levels probably as a response to increased generation of reactive oxygen species. Working during the evening and night shifts increases oxidative levels and burnout levels.

Clinical Study:

Antioxidant Ingredient Proven To Relieve Stress

Biomed Central 2009

Abstract: https://www.sciencedaily.com/releases/2009/09/090914194652.htm

Excerpt: "Several studies have shown that there is a link between psychological stress and intracellular oxidative stress. We wanted to test whether augmenting the body's ability to deal with oxidative species might help a person's ability to resist burnout

Sleep Disorders & Oxidative Stress

Scientific Review:

The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis

Sleep medicine reviews (Journal) 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/29759891/

Full Review: https://core.ac.uk/reader/154424977?utm_source=linkout

Excerpt: In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders.

 

 

Scientific Review:

Sleep deprivation, oxidative stress and inflammation

Advances in protein chemistry and structural biology (Journal) 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/31997771/

Excerpt: Role of oxidative stress and inflammation has been implicated in sleep deprivation-related impairments. This review article presents a detailed description of the current state of the literature on the subject.

 

Scientific Review:

Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

American Sleep Apnea Association 2013

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/23371889/

Excerpt: Moreover, Reactive Oxygen Specis (ROS) are also produced in the sleep deprivation process. The aim of this article is to review pathways and mechanisms that may point to oxidative stress as a link between sleep deprivation and cancer.

 

Scientific Review:

Sleep deprivation and oxidative stress in animal models: a systematic review

Oxidative medicine and cellular longevity (Journal) 2015

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/25945148/

Full Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402503/

Excerpt: The complex relationship between sleep duration and oxidative stress is discussed. Further studies should consider molecular and genetic approaches to determine whether disrupted sleep promotes oxidative stress.

Diabetes & Oxidative Stress

Scientific Review:

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

Oxidative medicine and cellular longevity (Journal) 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/32215179/

Full Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085395/

Excerpt: Insulin resistance has a complex pathophysiology, and it is contributed to by multiple factors including oxidative stress. Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of  Type 2 Diabetes (T2DM) via several molecular mechanisms. 

Scientific Review:

Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

Journal of cellular biochemistry 2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/28460155/

... Therefore, we conclude that measurement of oxidative stress biomarkers may be one of the optional tool for the diagnosis and prediction of Type 2 Diabetes (T2DM). Moreover, the key findings described in this article also provides a new conceptual framework for forthcoming investigations on the role of oxidative stress in pathogenesis of T2DM and drug discovery.

Scientific Review:

Diabetes, oxidative stress and therapeutic strategies

Biochimica et biophysica acta (Journal) 2014

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24905298/

Excerpt: Oxidative stress results from either an increase in free radical production, or a decrease in endogenous antioxidant defenses, or both. In type 2 diabetic patients, oxidative stress is closely associated with chronic inflammation

Scientific Review: 

Targeting oxidative stress through antioxidants in diabetes mellitus

Journal of drug targeting 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/29285960/

Excerpt: it is important to develop new fixed-dose combinations of effective antioxidants that target key reactive oxygen (or nitrogen)-producing sources, mimic endogenous antioxidants and scavenge the reactive species generated balancing the pro and antioxidant cycle. This review focuses on the preclinical and clinical trial data with therapeutic antioxidants in type 2 diabetes along with a brief focus on success and failures of antioxidant-based therapy.

Scientific Review:

Oxidative stress and inflammatory markers in prediabetes and diabetes

Journal of physiology and pharmacology 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/32084643/

Full Review: http://www.jpp.krakow.pl/journal/archive/12_19/pdf/10.26402/jpp.2019.6.01.pdf

Excerpt:  In this review, we discuss the relationship between oxidative stress and hyperglycemia along with links between inflammation and prediabetes

Scientific Review:

Oxidative Stress and Inflammation in Renal and Cardiovascular Complications of Diabetes

Biology (Journal) 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/33396868/

Full Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830433/

Excerpt: Emerging therapeutic strategies tackle these pathways in a variety of ways, from increasing antioxidant defenses (antioxidants and Nrf2 activators) to reducing ROS production.