Scientific Research &  Clinical Studies


Oxidative Stress and Low Glutathione in Common Ear, Nose, and Throat Conditions: A Systematic Review -

Search Glutathione/NAC and allergic rhinitis


The effect of Co-Q10 on allergic rhinitis and allergic asthma


Is depression associated with increased oxidative stress? A systematic review and meta-analysis

Psychoneuroendocrinology (Journal) 2015

Pub Med Abstract:

Full Article:

Excerpt: Background: It has been suggested that depressed persons have increased oxidative stress and decreased anti-oxidant defences. Conclusion: This meta-analysis finds that oxidative stress, as measured by 8-OHdG and F2-isoprostanes, is increased in depression. 

Scientific Review:

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

Progress in neuro-psychopharmacology & biological psychiatry (Journal) 2016

Pub Med Abstract only:

Excerpt: Since, aging and Major Depressive Disorder (MDD) share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising.

Clinical Study:

A pilot study of cortical glutathione in youth with depression

Psychiatry research. Neuroimaging (Journal) 2017

Pub Med Abstract Clinical study results:

Full Study results ( Of note page 2 Intro) :

Excerpt: Results: Occipital  Glutathione (GSH) levels were lower in adolescents with Major Depressive Disorder (MDD) compared to controls, but did not correlate with anhedonia. Although preliminary, findings add new data to support the role of oxidative stress in MDD and suggest that lower GSH may be a potential marker 


Scientific Review:

Markers of Oxidative Stress and Neuroprogression in Depression Disorder

Oxidative medicine and cellular longevity (Journal) 2015

Pub Med Abstract:

Full Article ( Of note Chapter 5 Effect of Antioxidants)

Excerpt: Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species. Products of oxidative stress represent important parameters for measuring and predicting of depression status......


Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis

The Journal of clinical psychiatry 2014

Pub Med Abstract:

Original Study:

Excerpt: Objective: To investigate the role of oxidative stress and antioxidants in depression. Conclusions: Results suggest that oxidative stress plays a role in depression and that antidepressant activity may be mediated via improving oxidative stress/antioxidant function.

Clinical Study:

The relevance of oxidative stress status in first episode and recurrent depression

Journal of affective disorders 2012

Pub Med Abstract only:

Excerpt: Our work provides additional evidences of increased oxidative stress in Major Depressive Disorder (MDD), expressed by altered antioxidant enzyme activity and increased levels of lipid peroxidation. Also, it seems that sub-classifying depression into different subtypes, based on chronicity, can predict differences in the levels of some various oxidative stress markers.


Clinical Study:

The association between inflammatory markers and depression with and without posttraumatic stress disorder

Pharmacological reports : PR ( Journal) 2018

Pub Med Clinical Study Results:

Excerpt: Conclusion: Depression both with and without PTSD leads to elevated levels of inflammation and an oxidant/antioxidant imbalance. Alterations in both cytokines and oxidative stress are related to the mechanisms responsible for the development of depressive symptoms.



Clinical Study:

Oxidative & nitrosative stress in depression: why so much stress?

Neuroscience and biobehavioral reviews (Journal) 2014

Pub Med Abstract only:

Excerpt: Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, 



Clinical Study:

Evaluation of biochemical markers of oxidative and nitrosative stress pathways in major depression

International Journal of Medical and Health Sciences 2014

Clinical study results:

Excerpt: Major depression is characterized by decreased antioxidant status, an induction of the oxidative and nitrosative pathways. Abnormal levels of antioxidant enzymes and lipid peroxidation further substantiate the role of free radical in major depression