Scientific Research &  Clinical Studies

OXIDATIVE STRESS & HEART AGING

Review: 

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Life Journal (Basel, Switzerland) 2021

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/33467601/

Full Article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829951/

Review:

Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases

Oxidative medicine and cellular longevity (Journal ) 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/32454933/

Full Article (Of Note 7.1. Antioxidants as Pharmacological Tools): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232723/#sec7title


Co ENZYME Q10 & HEART HEALTH

 

 

Clinical Trial:

The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial

Journal of the American College of Cardiology (Heart Failure) 2014

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/25282031/

Full Clinical Study Results: https://reader.elsevier.com/reader/sd/pii/S2213177914003369?token=48B330992D198D96775F08001A1F5365FE820F56BDE84519529E6FB19ABB45D7FE1F5A7F0FBB3CB60B24B7F8E8FACA34

Clinical Review:

Coenzyme Q10 and Heart Failure: A State-of-the-Art Review

American Heart Association - Heart Failure (Journal) 2016

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/27012265/

Full Study Review: https://www.ahajournals.org/doi/epub/10.1161/CIRCHEARTFAILURE.115.002639

Full study Review on AHA website: https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.115.002639?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed


Pre-Clinical Study:

UBIQUINOL (CoQ10) INNOVATIVE FORM PROVIDES CARDIOPROTECTION BY A SINGLE INTRAVENOUS INJECTION

Journal of Hypertension June 2018

Journal Abstract: https://journals.lww.com/jhypertension/Abstract/2018/06001/UBIQUINOL_INNOVATIVE_FORM_PROVIDES.771.aspx

Pre-Clinical Study:

Single intravenous injection of coenzyme Q10 protects the myocardium after irreversible ischemia

Bulletin of experimental biology and medicine (Journal) 2013

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/24288763/


Clinical Trial:

Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study

The Clinical investigator Journal (1993)

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/8241697/

Clinical Review:

Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

Journal of clinical medicine 2020

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/32349341/

Full Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287951/

Clinical Study:

Coenzyme Q10: an independent predictor of mortality in chronic heart failure

Journal of the American College of Cardiology 2008

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/19017509/

Full Study Result: https://www.sciencedirect.com/science/article/pii/S0735109708027228?via%3Dihub

Clinical Review:

Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

International journal of clinical chemistry 2015

Pub Med Abstracthttps://pubmed.ncbi.nlm.nih.gov/26254995/


Clinical Review:

Atherosclerosis and Coenzyme Q 10

International journal of molecular sciences 2019

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/31635164/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834161/


GLUTATHIONE & HEART HEALTH

 

Clinical Study:

Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study

Stroke :American Heart Association  (Journal) 2004

 

Pubmed Abstract:  https://pubmed.ncbi.nlm.nih.gov/15256685/

Full Article:  https://www.ahajournals.org/doi/epub/10.1161/01.STR.0000138022.86509.2d 

https://pubmed.ncbi.nlm.nih.gov/15256685/

Scientific Review:

Glutathione "Redox Homeostasis" and Its Relation to Cardiovascular Disease

Oxidative medicine and cellular longevity (Journal ) 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/31210841/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532282/

Scientific Review:

(Glutathione) S-glutathionylation, friend or foe in cardiovascular health and disease

Society for Free Radical Biology and Medicine 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/32912836/

Full Article: https://www.sciencedirect.com/science/article/pii/S2213231720308983?via%3Dihub

Clinical Study:

Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities

Public Library of Science - PloS One (Journal) 2009

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/19319187/

Full Article (Of note - Blood glutathione deficiency in patients with cardiac disease) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655715/

Clinical Study:

The relationship between plasma levels of oxidized and reduced thiols (Glutathione) and early atherosclerosis in healthy adults

Journal of the American College of Cardiology 2006

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/16516085/

Full Study Results: https://www.sciencedirect.com/science/article/pii/S0735109705028275?via%3Dihub

Clinical Study:

Elevated peroxidative glutathione redox status in atherosclerotic patients with increased thickness of carotid intima media

Chinese medical journal 2009

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/20092785/


Scientific Study:

Atrial glutathione content, calcium current, and contractility

The Journal of biological chemistry 2007

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/17656369/

Full Data: https://www.jbc.org/article/S0021-9258(20)58703-6/fulltext#secelsvev3356


OXIDATIVE STRESS & BLOOD VESSELS

 

 

Scientific Review:

Oxidative stress and vascular inflammation in aging

Free radical biology & medicine (Journal 2013)

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/23851032/

Scientific Review:

The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad

American College of Clinical Gerontology (Journal) 2013

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/22453933/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636404/


NAD+ & HEART HEALTH

 

 

Scientific Review:

Emerging potential benefits of modulating NAD + metabolism in cardiovascular disease

American journal of physiology. Heart and circulatory physiology 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/29351465/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966770/

Scientific Review:

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

Archives of cardiovascular diseases 2016

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/26707577/

Full Article: https://reader.elsevier.com/reader/sd/pii/S1875213615002053?token=BF986BE11B495B5BB39D8D0E7FBE235667D2F9A85F9FEED1A908A95D1EF4484B0EF176E89D3DEF97B79F9F54F8BC02C5


ATRIAL FIBRILLATION LINK WITH OXIDATIVE STRESS

 

 

Scientific Review: 

The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation

International journal of cardiology 2007

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/16764958/

Scientific Review:

Oxidative stress: a possible pathogenesis of atrial fibrillation

Medical hypotheses (Journal) 2009

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/19103473/


Scientific Review:

Antioxidant interventions as novel preventive strategies for postoperative atrial fibrillation

International journal of cardiology 2010

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/19616323/

Clinical Multicenter Study:

Association between oxidative stress and atrial fibrillation

Heart Rhythm Society (Journal) 2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/28757307/

Full Study Results: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817893/