Scientific Research &  Clinical Studies

BRAIN & NERVE FUNCTION

Scientific Review:

Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?

Current drug targets (Journal) 2017

Pub Med Abstracthttps://pubmed.ncbi.nlm.nih.gov/27033198/

Scientific Review:

Oxidative Stress and the Central Nervous System

The Journal of pharmacology and experimental therapeutics 2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/27754930/

FullArticle https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193071/#idm140654852238528title

Scientific Review:

Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD

Harvard review of psychiatry 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/29016379/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843493/


Scientific Review:

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Molecules : a journal of synthetic chemistry and natural product chemistry 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/31013638/

Full Article

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514564/#idm140339105441424title

Scientific Review:

13 reasons why the brain is susceptible to oxidative stress

Society for Free Radical Biology and Medicine (Journal) 2018

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/29413961/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881419/

Scientific Review:

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Oxidative medicine and cellular longevity (Journal) 2017

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/28785371/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529664/


GLUTATHIONE & BRAIN FUNCTION

Scientific Review:

Endogenous Glutathione pathways in the brain

Biological chemistry (Journal) 2003

Pubmed Abstract only: https://pubmed.ncbi.nlm.nih.gov/12751781/

Scientific Review:

Impaired Glutathione Synthesis in Neurodegeneration

International journal of molecular sciences 2013

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/24145751/ 

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821656/

Scientific Review:

Multiple roles of glutathione in the central nervous system

Biological chemistry (Journal) 1997

Pub Med abstract: https://pubmed.ncbi.nlm.nih.gov/9377474/


Clinical Study:

Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

Journal of neuropsychopharmacology

2011

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/20633320/

Clinical Study:

Do glutathione levels decline in aging human brain?

Free radical biology & medicine (Journal) 2016

Pub Med Abstract : https://pubmed.ncbi.nlm.nih.gov/26845616/

Scientific Review:

Glutathione redox imbalance in brain disorders

Current opinion in clinical nutrition and metabolic care (Journal) 2015

Pub Med Abstract only: https://pubmed.ncbi.nlm.nih.gov/25405315/


Scientific Review:

Functional consequences of age-dependent changes in glutathione status in the brain

Antioxidants & redox signaling (Journal) 2013

Pub Med Abstract only: https://pubmed.ncbi.nlm.nih.gov/23249101

/

Pre-Clinical Study:

Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in App NL-G-F/NL-G-F knock-in mice

Neuropharmacology 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/32130977/

Scientific Review:

Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy

Analytical biochemistry (Journal) 1997

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/28034792/


NAD+ & BRAIN FUNCTION

Scientific Review:

Endogenous NAD + in Brain Aging and Neurodegenerative Disorders

Cell metabolism (Journal) 2019

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/31577933/

Full Article:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787556/#ABS1title

Scientific Review:

Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration

Antioxidants & redox signaling 2018

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/28548540/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962335/

Scientific Review:

NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences

Antioxidants & redox signaling (Journal) 2008

Pub Med Abstract only: https://pubmed.ncbi.nlm.nih.gov/18020963/


Co ENZYME Q10 & BRAIN FUNCTION

Pre-Clinical Study:

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Proceedings of the National Academy of Sciences of the United States of America 1998

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/9671775/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21173/

Pre-Clinical Study:

Intravenous Treatment With Coenzyme Q10 Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Brain Ischemia in Rats

Journal of cardiovascular pharmacology 2016

Pub Med Abstract:  https://pubmed.ncbi.nlm.nih.gov/26371950/

Pre-Clinical study:

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality

Antioxidants (Journal) 2020

Pub Med Abstract: https://pubmed.ncbi.nlm.nih.gov/33297323/

Full Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762283/